Reproductive toxicity, mutagenicity and antigenicity of pamiteplase (genetical recombination).

Ishikawa, A; Fujiwara, M; Ohata, T; Wakata, A; Hoshino, K; Matsuzawa, T; Barrow, P C; Shimazu, H; Ono, C; Putman, D L; San, R H; Couch, R C

Ishikawa, A; Fujiwara, M; Ohata, T; Wakata, A; Hoshino, K; Matsuzawa, T; Barrow, P C; Shimazu, H; Ono, C; Putman, D L; San, R H; Couch, R C.

Affiliation

Ishikawa A; Medicinal Safety Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.

J Toxicol Sci ; 22(3): 207-17, 1997 Aug.

Article in En | MEDLINE | ID: mdl-9279823

Subject(s)

Mutagenesis/drug effects; Reproduction/drug effects; Tissue Plasminogen Activator/toxicity; Abnormalities, Drug-Induced; Animals; Antibodies/analysis; Chromosome Aberrations; Female; Humans; Male; Mice; Mice, Inbred ICR; Pan troglodytes; Pregnancy; Rabbits; Rats; Rats, Sprague-Dawley; Recombinant Proteins/immunology; Recombinant Proteins/toxicity; Tissue Plasminogen Activator/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Reproduction / Mutagenesis / Tissue Plasminogen Activator Limits: Animals / Female / Humans / Male / Pregnancy Language: En Journal: J Toxicol Sci Year: 1997 Document type: Article Affiliation country: Japan Country of publication: Japan

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