Drug-phospholipid interactions. 2. Predicting the sites of drug distribution using n-octanol/water and membrane/water distribution coefficients.

Barton, P; Davis, A M; McCarthy, D J; Webborn, P J

Barton, P; Davis, A M; McCarthy, D J; Webborn, P J.

Affiliation

Barton P; Department of Physical and Metabolic Sciences, Astra Chamwood, Loughborough, Leicestershire, United Kingdom.

J Pharm Sci ; 86(9): 1034-9, 1997 Sep.

Article in En | MEDLINE | ID: mdl-9294818

Subject(s)

Octanols/chemistry; Pharmaceutical Preparations/chemistry; Phospholipids/chemistry; Adipose Tissue/metabolism; Animals; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Indicators and Reagents; Kinetics; Membranes, Artificial; Models, Biological; Rats; Water/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Phospholipids / Pharmaceutical Preparations / Octanols Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: J Pharm Sci Year: 1997 Document type: Article Affiliation country: United kingdom Country of publication: United States

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