Additive effect of beraprost on pulmonary vasodilation by inhaled nitric oxide in children with pulmonary hypertension.

Ichida, F; Uese, K; Tsubata, S; Hashimoto, I; Hamamichi, Y; Fukahara, K; Murakami, A; Miyawaki, T

Ichida, F; Uese, K; Tsubata, S; Hashimoto, I; Hamamichi, Y; Fukahara, K; Murakami, A; Miyawaki, T.

Affiliation

Ichida F; Department of Pediatrics, Toyama Medical and Pharmaceutical University, Japan.

Am J Cardiol ; 80(5): 662-4, 1997 Sep 01.

Article in En | MEDLINE | ID: mdl-9295007

ABSTRACT

ABSTRACT

Combined administration of inhaled nitric oxide and beraprost sodium resulted in a more intense decrease in pulmonary vascular resistance than nitric oxide given alone (mean -33% vs -45%, p <0.05), without serious systemic hypotension. Combined therapy with nitric oxide and beraprost sodium is highly desirable in treating primary and secondary pulmonary hypertension in children.

Subject(s)

Epoprostenol/analogs & derivatives; Hypertension, Pulmonary/drug therapy; Lung/physiology; Nitric Oxide/pharmacology; Vasodilation/drug effects; Vasodilator Agents/pharmacology; Child; Child, Preschool; Cyclic AMP/blood; Cyclic GMP/blood; Drug Synergism; Epoprostenol/pharmacology; Humans; Infant; Lung/drug effects; Vascular Resistance

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Collection: 01-internacional Database: MEDLINE Main subject: Vasodilation / Vasodilator Agents / Epoprostenol / Hypertension, Pulmonary / Lung / Nitric Oxide Limits: Child / Child, preschool / Humans / Infant Language: En Journal: Am J Cardiol Year: 1997 Document type: Article Affiliation country: Japan

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