Pharmacokinetics and metabolism of the new thromboxane A2 receptor antagonist ramatroban in animals. 1st communication: absorption, concentrations in plasma, metabolism, and excretion after single administration to rats and dogs.

Boberg, M; Ahr, H J; Beckermann, B; Bühner, K; Siefert, H M; Steinke, W; Wünsche, C; Hirayama, M

Boberg, M; Ahr, H J; Beckermann, B; Bühner, K; Siefert, H M; Steinke, W; Wünsche, C; Hirayama, M.

Affiliation

Boberg M; Bayer AG, Pharma Product Development and Research, Wuppertal, Germany.

Arzneimittelforschung ; 47(8): 928-38, 1997 Aug.

Article in En | MEDLINE | ID: mdl-9296279

Subject(s)

Carbazoles/pharmacokinetics; Receptors, Thromboxane/antagonists & inhibitors; Sulfonamides/pharmacokinetics; Thromboxane A2/metabolism; Administration, Oral; Animals; Biological Availability; Biotransformation; Carbazoles/blood; Carbazoles/urine; Chromatography, High Pressure Liquid; Dogs; Enterohepatic Circulation; Female; In Vitro Techniques; Injections, Intravenous; Intestinal Absorption; Liver/cytology; Liver/metabolism; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Rats; Rats, Wistar; Receptors, Thromboxane/metabolism; Sex Characteristics; Species Specificity; Spectrophotometry, Ultraviolet; Sulfonamides/blood; Sulfonamides/urine

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Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Thromboxane A2 / Carbazoles / Receptors, Thromboxane Limits: Animals Language: En Journal: Arzneimittelforschung Year: 1997 Document type: Article Affiliation country: Germany Country of publication: Germany

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