Conjugation of blocked ricin to an anti-CD19 monoclonal antibody increases antibody-induced cell calcium mobilization and CD19 internalization.

Goulet, A C; Goldmacher, V S; Lambert, J M; Baron, C; Roy, D C; Kouassi, E

Goulet, A C; Goldmacher, V S; Lambert, J M; Baron, C; Roy, D C; Kouassi, E.

Affiliation

Goulet AC; Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada.

Blood ; 90(6): 2364-75, 1997 Sep 15.

Article in En | MEDLINE | ID: mdl-9310487

Subject(s)

Antigens, CD19/physiology; Antigens, CD; Calcium/metabolism; Immunotoxins/chemistry; Ricin/chemistry; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Antibodies, Monoclonal/chemistry; Antigens, CD20/immunology; Antigens, Differentiation/immunology; Dimerization; Enzyme Inhibitors/pharmacology; Humans; Immunotoxins/metabolism; Lactose/pharmacology; Membrane Glycoproteins; NAD+ Nucleosidase/immunology; Protein Synthesis Inhibitors/pharmacology; Protein-Tyrosine Kinases/antagonists & inhibitors; Signal Transduction; Structure-Activity Relationship; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Ricin / Antigens, CD / Immunotoxins / Calcium / Antigens, CD19 Limits: Humans Language: En Journal: Blood Year: 1997 Document type: Article Affiliation country: Canada

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