Potentiation of ara-C-induced apoptosis by the protein kinase C activator bryostatin 1 in human leukemia cells (HL-60) involves a process dependent upon c-Myc.

Chelliah, J; Freemerman, A J; Wu-Pong, S; Jarvis, W D; Grant, S

Chelliah, J; Freemerman, A J; Wu-Pong, S; Jarvis, W D; Grant, S.

Affiliation

Chelliah J; Department of Medicine, Medical College of Virginia, Richmond 23298, U.S.A.

Biochem Pharmacol ; 54(5): 563-73, 1997 Sep 01.

Article in En | MEDLINE | ID: mdl-9337072

Subject(s)

Apoptosis/drug effects; Cell Cycle/drug effects; Cytarabine/pharmacology; Diterpenes; HL-60 Cells/drug effects; Lactones/pharmacology; Oligonucleotides, Antisense/pharmacology; Protein Kinase C/metabolism; Proto-Oncogene Proteins c-myc/metabolism; Antineoplastic Agents/pharmacology; Bryostatins; DNA Fragmentation; Drug Synergism; Enzyme Activation; Humans; Kinetics; Macrolides; Phorbol 12,13-Dibutyrate/pharmacology; Proto-Oncogene Proteins c-myc/genetics; Terpenes/pharmacology; Tetradecanoylphorbol Acetate/pharmacology; Thionucleotides

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Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase C / Cell Cycle / Oligonucleotides, Antisense / Proto-Oncogene Proteins c-myc / Apoptosis / HL-60 Cells / Cytarabine / Diterpenes / Lactones Limits: Humans Language: En Journal: Biochem Pharmacol Year: 1997 Document type: Article Affiliation country: United States Country of publication: United kingdom

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