HIV-1 risk and vaccine acceptability in the Ugandan military.
J Acquir Immune Defic Syndr Hum Retrovirol
; 15(5): 375-80, 1997 Aug 15.
Article
in En
| MEDLINE
| ID: mdl-9342258
ABSTRACT
Between July and October 1993, 570 19- to 22-year-old volunteers were screened for HIV-1, with a resulting seroprevalence rate of 18.3% (95% CI 14.0%, 22.6%). A cohort of 249 HIV-1-noninfected military recruits in the Ugandan Peoples' Defense Forces was followed prospectively for up to 18 months to document rates of HIV-1 seroprevalence, seroconversion, and knowledge and attitudes related to vaccine acceptability. The HIV-1 seroincidence rate was 3.56 per 100 person-years (95% CI 1.49, 5.62) over 309 person-years of observation. At the 3- and 12-month visits, subjects were interviewed on issues of acceptance and knowledge about vaccines, including anti-HIV vaccines in particular. More than 90% believe that HIV vaccines will not cause HIV infection, and if offered, 88% report that they would take the vaccine if they were not already infected. Nonvaccine prevention methods were considered less reliable; monogamy and condom use were considered effective by only 33.5% and 69.3% of the cohort respectively. After completing the vaccine acceptability questionnaire at the 12-month visit, subjects were offered an approved polyvalent meningococcal vaccine as an indicator of general vaccine acceptance. All subjects reported receiving at least one previous vaccination, and 95% willingly accepted the meningococcal vaccination. The Ugandan military is a stable population at substantial risk for HIV-1 infection and may be a suitable population for vaccine efficacy trials.
Key words
Africa; Africa South Of The Sahara; Barrier Methods; Behavior; Condom; Contraception; Contraceptive Methods; Delivery Of Health Care; Developing Countries; Diseases; Eastern Africa; English Speaking Africa; Family Planning; Government; Health; Health Services; Hiv Infections--men; Hiv Infections--prevention and control; Immunization; Knowledge--men; Military Personnel--men; Political Factors; Primary Health Care; Prospective Studies; Research Methodology; Research Report; Risk Behavior--men; Sex Behavior--men; Studies; Uganda; Vaccination; Vaccines; Viral Diseases
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Infections
/
HIV-1
/
AIDS Vaccines
/
Military Personnel
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
Africa
Language:
En
Journal:
J Acquir Immune Defic Syndr Hum Retrovirol
Journal subject:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
/
VIROLOGIA
Year:
1997
Document type:
Article
Affiliation country:
United States