A girl with diabetes and severe combined immunodeficiency from adenosine deaminase deficiency.
J Pediatr Endocrinol Metab
; 10(4): 425-8, 1997.
Article
in En
| MEDLINE
| ID: mdl-9364370
ABSTRACT
We present a girl with severe combined immunodeficiency (SCID) from adenosine deaminase (ADA) deficiency who developed insulin dependent diabetes mellitus (IDDM). This combination of features has not been previously reported. Because HLA typing (DQbeta-57 Asp/Asp and DQalpha-52 Ser/Ser) showed no alleles usually associated with IDDM, and ICA were repeatedly negative even after treatment with PEG-ADA and gene transplant, hypotheses on the pathogenesis of diabetes mellitus in this patient are discussed.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Severe Combined Immunodeficiency
/
Diabetes Mellitus, Type 1
Limits:
Child
/
Female
/
Humans
Language:
En
Journal:
J Pediatr Endocrinol Metab
Journal subject:
ENDOCRINOLOGIA
/
PEDIATRIA
Year:
1997
Document type:
Article
Affiliation country:
Italy