Active site cavity of herpesvirus proteases revealed by the crystal structure of herpes simplex virus protease/inhibitor complex.

Hoog, S S; Smith, W W; Qiu, X; Janson, C A; Hellmig, B; McQueney, M S; O'Donnell, K; O'Shannessy, D; DiLella, A G; Debouck, C; Abdel-Meguid, S S

Hoog, S S; Smith, W W; Qiu, X; Janson, C A; Hellmig, B; McQueney, M S; O'Donnell, K; O'Shannessy, D; DiLella, A G; Debouck, C; Abdel-Meguid, S S.

Affiliation

Hoog SS; Department of Macromolecular Sciences, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA.

Biochemistry ; 36(46): 14023-9, 1997 Nov 18.

Article in En | MEDLINE | ID: mdl-9369473

Subject(s)

Capsid/chemistry; Herpesvirus 1, Human/enzymology; Herpesvirus 2, Human/enzymology; Organophosphorus Compounds/chemistry; Serine Endopeptidases/chemistry; Viral Proteins; Binding Sites; Capsid/genetics; Crystallography, X-Ray; Models, Molecular; Molecular Sequence Data; Protease Inhibitors; Protein Conformation; Recombinant Proteins/chemistry; Serine Endopeptidases/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Organophosphorus Compounds / Viral Proteins / Serine Endopeptidases / Capsid / Herpesvirus 2, Human / Herpesvirus 1, Human Language: En Journal: Biochemistry Year: 1997 Document type: Article Affiliation country: United States

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