Entamoeba histolytica: computer-assisted modeling of phosphofructokinase for the prediction of broad-spectrum antiparasitic agents.

Byington, C L; Dunbrack, R L; Whitby, F G; Cohen, F E; Agabian, N

Byington, C L; Dunbrack, R L; Whitby, F G; Cohen, F E; Agabian, N.

Affiliation

Byington CL; Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City 84132, USA. cbyington@med.utah.edu

Exp Parasitol ; 87(3): 194-202, 1997 Nov.

Article in En | MEDLINE | ID: mdl-9371084

Subject(s)

Antiprotozoal Agents/metabolism; Diphosphates/metabolism; Diphosphonates/metabolism; Entamoeba histolytica/enzymology; Etidronic Acid/metabolism; Imidazoles/metabolism; Phosphofructokinase-1/metabolism; Amino Acid Sequence; Animals; Binding Sites; Computer Simulation; Drug Design; Drug Evaluation, Preclinical; Entamoeba histolytica/cytology; Entamoeba histolytica/drug effects; Models, Molecular; Molecular Sequence Data; Phosphofructokinase-1/antagonists & inhibitors; Sequence Alignment; Sequence Homology, Amino Acid; Zoledronic Acid

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Collection: 01-internacional Database: MEDLINE Main subject: Etidronic Acid / Phosphofructokinase-1 / Diphosphates / Diphosphonates / Entamoeba histolytica / Imidazoles / Antiprotozoal Agents Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Exp Parasitol Year: 1997 Document type: Article Affiliation country: United States

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