The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines.

König, A; Schwartz, G K; Mohammad, R M; Al-Katib, A; Gabrilove, J L

König, A; Schwartz, G K; Mohammad, R M; Al-Katib, A; Gabrilove, J L.

Affiliation

König A; The Molecular Therapeutics Program, the Sloan-Kettering Institute, New York, NY, USA.

Blood ; 90(11): 4307-12, 1997 Dec 01.

Article in En | MEDLINE | ID: mdl-9373241

Subject(s)

Apoptosis/drug effects; Cyclin-Dependent Kinases/antagonists & inhibitors; Down-Regulation/drug effects; Enzyme Inhibitors/pharmacology; Flavonoids/pharmacology; Leukemia, B-Cell/pathology; Piperidines/pharmacology; Proto-Oncogene Proteins c-bcl-2/biosynthesis; Cell Survival; Humans; Leukemia, B-Cell/metabolism; RNA, Messenger/metabolism; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Flavonoids / Leukemia, B-Cell / Down-Regulation / Apoptosis / Cyclin-Dependent Kinases / Proto-Oncogene Proteins c-bcl-2 / Enzyme Inhibitors Limits: Humans Language: En Journal: Blood Year: 1997 Document type: Article Affiliation country: United States Country of publication: United States

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