[Acquired haemophilia A]. / Verworven hemofilie A.
Ned Tijdschr Geneeskd
; 141(27): 1342-4, 1997 Jul 05.
Article
in Nl
| MEDLINE
| ID: mdl-9380188
ABSTRACT
A 74-year-old man developed a severe bleeding disorder on the basis of acquired Factor VIII (F VIII) inhibitor. Coagulation assays showed a prolonged activated partial thromboplastin time (APTT) with a normal prothrombin time (PT);F VIII level was 0.07 IU and F VIII inhibitor level 8.8 Bethesda units (BU). At least half the cases of acquired haemophilia A are associated with pregnancy, the postpartum period or an underlying malignancy or autoimmune disease. Haemorrhagic diathesis can be severe and life-threatening. Treatment of acute haemorrhages consists of human or porcine factor VIII concentrate, activated prothrombin complex concentrate (FEIBA) or recombinant factor VIIa, depending on the antibody titre. Immunosuppressive therapy is successful in at least 60% of the patients in making the inhibitor disappear. In patients with a spontaneous haemorrhagic diathesis, a thorough medical history should be taken, coagulation assays should be performed and a specialist should be consulted.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Factor VIII
/
Hemophilia A
Type of study:
Diagnostic_studies
Limits:
Aged
/
Humans
/
Male
Language:
Nl
Journal:
Ned Tijdschr Geneeskd
Year:
1997
Document type:
Article