Mechanism of sodium channel blockade in the cardiotoxic action of emetine dihydrochloride in isolated cardiac preparations and ventricular myocytes of guinea pigs.

Lemmens-Gruber, R; Studenik, C; Karkhaneh, A; Heistracher, P

Lemmens-Gruber, R; Studenik, C; Karkhaneh, A; Heistracher, P.

Affiliation

Lemmens-Gruber R; Institute of Pharmacology and Toxicology, University of Vienna, Pharmazie-Zentrum, Austria.

J Cardiovasc Pharmacol ; 30(5): 554-61, 1997 Nov.

Article in En | MEDLINE | ID: mdl-9388036

Subject(s)

Amebicides/toxicity; Emetine/toxicity; Papillary Muscles/drug effects; Purkinje Cells/drug effects; Sodium Channel Blockers; Action Potentials/drug effects; Animals; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Ventricles/drug effects; In Vitro Techniques; Male; Microelectrodes; Papillary Muscles/physiology; Patch-Clamp Techniques; Purkinje Cells/physiology; Sodium Channels/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Papillary Muscles / Purkinje Cells / Sodium Channel Blockers / Emetine / Amebicides Limits: Animals Language: En Journal: J Cardiovasc Pharmacol Year: 1997 Document type: Article Affiliation country: Austria

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