CJ-12,954 and its congeners, new anti-Helicobacter pylori compounds produced by Phanerochaete velutina: fermentation, isolation, structural elucidation and biological activities.
J Antibiot (Tokyo)
; 50(10): 833-9, 1997 Oct.
Article
in En
| MEDLINE
| ID: mdl-9402988
ABSTRACT
Seven new phthalide compounds with anti-Helicobacter pylori activities were isolated from the basidiomycete Phanerochaete velutina CL6387. The two most potent phthalide compounds, CJ-12,954 and CJ-13,014, have MICs of 5 ng/ml. The structure-activity relationship shows that the presence of a spiroketal part in addition to the phthalide part, greatly enhances the activity. The phthalide compounds appear to be specific for H. pylori, since they did not show antibacterial activities when tested against a panel of other microorganisms.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Basidiomycota
/
Helicobacter pylori
/
Anti-Infective Agents
Language:
En
Journal:
J Antibiot (Tokyo)
Year:
1997
Document type:
Article
Affiliation country:
Japan