Interaction of Interceed oxidized regenerated cellulose with macrophages: a potential mechanism by which Interceed may prevent adhesions.
Am J Obstet Gynecol
; 177(6): 1315-20; discussion 1320-1, 1997 Dec.
Article
in En
| MEDLINE
| ID: mdl-9423730
ABSTRACT
OBJECTIVE:
The objective of the study was to determine whether Interceed oxidized regenerated cellulose (Johnson & Johnson Medical, Arlington, Tex.), because of its polyanionic nature, may compete for the macrophage scavenger receptor. STUDYDESIGN:
RAW macrophages were incubated with Interceed oxidized regenerated cellulose and known scavenger receptor ligands. The production of interleukin-1beta by mouse peritoneal macrophages was measured in the presence of Interceed cellulose.RESULTS:
When macrophages were incubated with Interceed cellulose, increasing concentrations inhibited the uptake of fluorescent acetyl low-density lipoprotein. In the presence of Interceed cellulose there was a decrease in the production of interleukin-1beta by mouse macrophages.CONCLUSION:
These results suggest that the interaction of Interceed oxidized regenerated cellulose with macrophages with scavenger receptors may result in a decreased secretion of matrix components, inflammatory mediators, and cellular growth factors. Thus Interceed cellulose may function as a biologic barrier in preventing adhesions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cellulose, Oxidized
/
Macrophages
Limits:
Animals
/
Humans
Language:
En
Journal:
Am J Obstet Gynecol
Year:
1997
Document type:
Article
Affiliation country:
United States