Characterization of a cDNA clone encoding pedal peptide in the terrestrial snail.
Neuroreport
; 8(16): 3631-5, 1997 Nov 10.
Article
in En
| MEDLINE
| ID: mdl-9427339
ABSTRACT
We report the isolation of a Helix lucorum cDNA clone encoding a precursor of neuropeptides that are closely related to Aplysia and Tritonia pedal peptides (Pep). The predicted propeptide contains 20 copies of the two variants of Helix Pep interspersed with Lys-Arg endopeptidase cleavage sites. Northern blot hybridization revealed multiple Pep-hybridizing species in the Helix CNS RNA. The Pep gene was expressed by several identified serotonergic neurones in pedal and cerebral ganglia, groups of sensory neurones in procerebrum, peripheral neurones in olfactory bulb, mantle and foot, and group of neurones in pedal ganglia presumably involved in locomotion control. Pep mRNA was detected in several neurones at the early stages of nervous system development.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neuropeptides
/
Ganglia, Invertebrate
/
Helix, Snails
Limits:
Animals
Language:
En
Journal:
Neuroreport
Journal subject:
NEUROLOGIA
Year:
1997
Document type:
Article
Affiliation country:
RUSSIA
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM