Human diversity in killer cell inhibitory receptor genes.
Immunity
; 7(6): 753-63, 1997 Dec.
Article
in En
| MEDLINE
| ID: mdl-9430221
ABSTRACT
The presence and expression of killer inhibitory receptor (KIR) and CD94NKG2 genes from 68 donors were analyzed using molecular typing techniques. The genes encoding CD94NKG2 receptors were present in each person, but KIR gene possession varied. Most individuals expressed inhibitory KIR for the three well-defined HLA-B and -C ligands, but noninhibitory KIR genes were more variable. Twenty different KIR phenotypes were defined. Two groups of KIR haplotypes were distinguished and occurred at relatively even frequency. Group A KIR haplotypes consist of six genes the main inhibitory KIR, one noninhibitory KIR, and a structurally divergent KIR. Allelic polymorphism within five KIR genes was detected. Group B comprises more noninhibitory KIR genes and contains at least one additional gene not represented in group A. The KIR locus therefore appears to be polygenic and polymorphic within the human population.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genetic Variation
/
Membrane Glycoproteins
/
Killer Cells, Natural
/
Receptors, Immunologic
/
Antigens, CD
/
Lectins, C-Type
Limits:
Humans
Language:
En
Journal:
Immunity
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
1997
Document type:
Article
Affiliation country:
United States