Annexins II and V inhibit cell migration.
Exp Cell Res
; 237(2): 259-63, 1997 Dec 15.
Article
in En
| MEDLINE
| ID: mdl-9434621
ABSTRACT
Cell motility is a crucial component involved in wound healing, development, and tumor metastasis. This study investigated whether extracellular annexins, members of a calcium- and phospholipid-binding family of proteins, play a role in the migration of Lewis lung carcinoma cells. Using assays for wound closure and migration through 8-micron pores, it was found that annexins II and V significantly (> 40%) inhibited migration of these highly metastatic cells. Additionally, anti-annexin II antibodies enhanced migration of these same cells in the wound closure assay, while an irrelevant antibody (anti-calmodulin) showed no effect. These effects may be due to annexin-membrane binding and inhibition of phospholipid movement that is necessary for the formation of membrane protrusions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Movement
/
Annexin A5
/
Annexin A2
Limits:
Animals
Language:
En
Journal:
Exp Cell Res
Year:
1997
Document type:
Article
Affiliation country:
United States