A phase I/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease.

Howell, T H; Fiorellini, J P; Paquette, D W; Offenbacher, S; Giannobile, W V; Lynch, S E

Howell, T H; Fiorellini, J P; Paquette, D W; Offenbacher, S; Giannobile, W V; Lynch, S E.

Affiliation

Howell TH; Department of Periodontology, Harvard School of Dental Medicine, Boston, MA, USA.

J Periodontol ; 68(12): 1186-93, 1997 Dec.

Article in En | MEDLINE | ID: mdl-9444594

Subject(s)

Furcation Defects/drug therapy; Insulin-Like Growth Factor I/therapeutic use; Platelet-Derived Growth Factor/therapeutic use; Administration, Topical; Adult; Alveolar Process/drug effects; Antibodies/analysis; Becaplermin; Bone Regeneration/drug effects; Double-Blind Method; Evaluation Studies as Topic; Female; Follow-Up Studies; Furcation Defects/physiopathology; Furcation Defects/surgery; Gels; Humans; Insulin-Like Growth Factor I/administration & dosage; Insulin-Like Growth Factor I/immunology; Male; Middle Aged; Periodontal Diseases/drug therapy; Periodontal Diseases/physiopathology; Periodontal Diseases/surgery; Pharmaceutical Vehicles; Platelet-Derived Growth Factor/administration & dosage; Platelet-Derived Growth Factor/immunology; Proto-Oncogene Proteins c-sis; Recombinant Proteins; Regeneration/drug effects; Safety; Surgical Flaps

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Collection: 01-internacional Database: MEDLINE Main subject: Platelet-Derived Growth Factor / Insulin-Like Growth Factor I / Furcation Defects Type of study: Clinical_trials / Diagnostic_studies / Evaluation_studies / Observational_studies / Prognostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: J Periodontol Year: 1997 Document type: Article Affiliation country: United States Country of publication: United States

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