Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice.

Tolosa, E; King, L B; Ashwell, J D

Tolosa, E; King, L B; Ashwell, J D.

Affiliation

Tolosa E; Laboratory of Immune Cell Biology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1152, USA.

Immunity ; 8(1): 67-76, 1998 Jan.

Article in En | MEDLINE | ID: mdl-9462512

Subject(s)

Apoptosis/physiology; Autoimmunity/immunology; Lymphoproliferative Disorders/immunology; Receptors, Glucocorticoid/physiology; Thymus Gland/cytology; Thymus Gland/immunology; Animals; Autoantibodies/biosynthesis; CD4-Positive T-Lymphocytes/cytology; CD4-Positive T-Lymphocytes/drug effects; CD4-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/cytology; CD8-Positive T-Lymphocytes/drug effects; CD8-Positive T-Lymphocytes/immunology; Cell Survival/physiology; DNA/immunology; DNA, Antisense/genetics; DNA, Antisense/metabolism; DNA, Antisense/pharmacology; Gene Expression; Glomerulonephritis/immunology; Glomerulonephritis/pathology; Lymphocyte Activation/drug effects; Lymphocyte Activation/immunology; Mice; Mice, Transgenic; Mitogens/pharmacology; Receptors, Antigen, T-Cell/physiology; Receptors, Glucocorticoid/biosynthesis; Receptors, Glucocorticoid/genetics; Stimulation, Chemical; Transgenes

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Collection: 01-internacional Database: MEDLINE Main subject: Thymus Gland / Receptors, Glucocorticoid / Autoimmunity / Apoptosis / Lymphoproliferative Disorders Limits: Animals Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 1998 Document type: Article Affiliation country: United States Country of publication: United States

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