Wegener's granulomatosis: anti-proteinase 3 antibodies are potent inductors of human endothelial cell signaling and leakage response.

Sibelius, U; Hattar, K; Schenkel, A; Noll, T; Csernok, E; Gross, W L; Mayet, W J; Piper, H M; Seeger, W; Grimminger, F

Sibelius, U; Hattar, K; Schenkel, A; Noll, T; Csernok, E; Gross, W L; Mayet, W J; Piper, H M; Seeger, W; Grimminger, F.

Affiliation

Sibelius U; Department of Internal Medicine, Justus-Liebig-University, D-35392 Giessen, Germany.

J Exp Med ; 187(4): 497-503, 1998 Feb 16.

Article in En | MEDLINE | ID: mdl-9463400

Subject(s)

Antibodies, Antineutrophil Cytoplasmic/immunology; Antibodies, Monoclonal/immunology; Endothelium, Vascular/immunology; Granulomatosis with Polyangiitis/immunology; Serine Endopeptidases/immunology; Signal Transduction; Cell Communication; Cells, Cultured; E-Selectin/metabolism; Endothelium, Vascular/drug effects; Endothelium, Vascular/pathology; Enzyme-Linked Immunosorbent Assay; Granulomatosis with Polyangiitis/pathology; Humans; Myeloblastin; Phosphatidylinositols/metabolism; Platelet Activating Factor/metabolism; Polymerase Chain Reaction; Tumor Necrosis Factor-alpha/pharmacology; Vascular Cell Adhesion Molecule-1/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endothelium, Vascular / Serine Endopeptidases / Signal Transduction / Granulomatosis with Polyangiitis / Antibodies, Antineutrophil Cytoplasmic / Antibodies, Monoclonal Limits: Humans Language: En Journal: J Exp Med Year: 1998 Document type: Article Affiliation country: Germany Country of publication: United States

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