Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor.

Krause, R M; Buisson, B; Bertrand, S; Corringer, P J; Galzi, J L; Changeux, J P; Bertrand, D

Krause, R M; Buisson, B; Bertrand, S; Corringer, P J; Galzi, J L; Changeux, J P; Bertrand, D.

Affiliation

Krause RM; Department of Physiology, University Medical Center, 1211 Geneva 4, Switzerland.

Mol Pharmacol ; 53(2): 283-94, 1998 Feb.

Article in En | MEDLINE | ID: mdl-9463487

Subject(s)

Ivermectin/pharmacology; Receptors, Nicotinic/drug effects; Allosteric Regulation/drug effects; Animals; Anthelmintics/pharmacology; Binding Sites; Cell Line; Cell Membrane/chemistry; Chickens; Chloride Channels/physiology; Humans; Ion Channel Gating; Membrane Potentials; Models, Molecular; Neurons/drug effects; Neurons/physiology; Nicotinic Agonists/pharmacology; Oocytes; Point Mutation; Receptors, Nicotinic/chemistry; Recombinant Proteins; Solubility; Structure-Activity Relationship; Transfection; Xenopus laevis; alpha7 Nicotinic Acetylcholine Receptor

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Collection: 01-internacional Database: MEDLINE Main subject: Ivermectin / Receptors, Nicotinic Limits: Animals / Humans Language: En Journal: Mol Pharmacol Year: 1998 Document type: Article Affiliation country: Switzerland Country of publication: United States

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