Telomere DNA sequences and the concept of ontogenetic reserve cells.
Biochemistry (Mosc)
; 62(11): 1285-90, 1997 Nov.
Article
in En
| MEDLINE
| ID: mdl-9467852
ABSTRACT
Dynamics of telomere sequences are considered in normal and immortalized cells. Immortalized cells are suggested to be derived mainly from a special subpopulation of ontogenetic reserve cells. Their epigenetic program consists of autoregeneration during external stimulus for genome reorganization and corresponding appearance of genetic variants of cells. It is suggested that cells surviving the crisis stage contain a special signal sequence integrated into telomere DNA. Its elimination during shortening of DNA telomere sequences in dividing ontogenetic reserve cells is a signal for the cooperative transition of chromatin into a new steady state that corresponds to the epigenotype of immortalized cells. Localization of telomere DNA sequences in intrachromosomal "hot spots" reflects phylogenetic rearrangement of the genome.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA
/
Telomere
Limits:
Animals
/
Humans
Language:
En
Journal:
Biochemistry (Mosc)
Year:
1997
Document type:
Article
Affiliation country:
RUSSIA