Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development.
Genes Dev
; 12(4): 473-9, 1998 Feb 15.
Article
in En
| MEDLINE
| ID: mdl-9472016
ABSTRACT
The transcription factor SCL/tal-1 is essential for blood cell development. Though it is also expressed in vascular endothelium, SCL has been considered dispensable for vessel formation. Through transgenic rescue of hematopoietic defects of SCL-/- embryos and analysis of chimeras generated with SCL-/- ES cells tagged with a transgene expressed in vascular endothelial cells, we show that SCL is essential for angiogenic remodeling of the yolk sac capillary network into complex vitelline vessels. These findings establish a role for SCL in embryonic angiogenesis and argue for critical functions in both embryonic blood and vascular cells, the descendents of the presumptive hemangioblast.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
Endothelium, Vascular
/
Proto-Oncogene Proteins
/
Neovascularization, Physiologic
/
DNA-Binding Proteins
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Genes Dev
Journal subject:
BIOLOGIA MOLECULAR
Year:
1998
Document type:
Article
Affiliation country:
United States