Binding of dihydroartemisinin to hemoglobin H: role in drug accumulation and host-induced antimalarial ineffectiveness of alpha-thalassemic erythrocytes.

Vattanaviboon, P; Wilairat, P; Yuthavong, Y

Vattanaviboon, P; Wilairat, P; Yuthavong, Y.

Affiliation

Vattanaviboon P; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Mol Pharmacol ; 53(3): 492-6, 1998 Mar.

Article in En | MEDLINE | ID: mdl-9495816

Subject(s)

Antimalarials/metabolism; Artemisinins; Erythrocytes/metabolism; Hemoglobin H/metabolism; Sesquiterpenes/metabolism; alpha-Thalassemia/blood; Animals; Antimalarials/pharmacology; Plasmodium falciparum/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Hemoglobin H / Alpha-Thalassemia / Artemisinins / Erythrocytes / Antimalarials Limits: Animals Language: En Journal: Mol Pharmacol Year: 1998 Document type: Article Affiliation country: Thailand Country of publication: United States

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