Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat.
Neuroimmunomodulation
; 4(4): 181-7, 1997.
Article
in En
| MEDLINE
| ID: mdl-9524962
ABSTRACT
The serum antibody response to ovalbumin (OA) has been investigated following intracerebroventricular (i.c.v.) and intravenous administration of antigen in the rat, under altered neuronal and immunological conditions. I.c.v. administration of antigen was far more potent in eliciting humoral immune response. Central nervous system (CNS) immunization under the conditions of disrupted blood-brain barrier decreased anti-OA antibody production. Peripheral polyclonal stimulation with Bordetella pertussis increased production of specific antibodies to i.c.v. injected antigen, while complete Freund's adjuvant had no effect on the immune response. These results suggest that CNS compartmentalization of antigen may be critical for mounting strong antibody production, and that peripheral polyclonal stimulation of the immune system may markedly contribute to the overall intensity of the immune response.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovalbumin
/
Neurons
Limits:
Animals
Language:
En
Journal:
Neuroimmunomodulation
Journal subject:
ALERGIA E IMUNOLOGIA
/
NEUROLOGIA
Year:
1997
Document type:
Article
Affiliation country:
Yugoslavia