A Gly --> Ser change causes defective folding in vitro of calcium-binding epidermal growth factor-like domains from factor IX and fibrillin-1.

Whiteman, P; Downing, A K; Smallridge, R; Winship, P R; Handford, P A

Whiteman, P; Downing, A K; Smallridge, R; Winship, P R; Handford, P A.

Affiliation

Whiteman P; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom.

J Biol Chem ; 273(14): 7807-13, 1998 Apr 03.

Article in En | MEDLINE | ID: mdl-9525872

Subject(s)

Epidermal Growth Factor/chemistry; Factor IX/chemistry; Microfilament Proteins/chemistry; Protein Folding; Amino Acid Substitution; Epidermal Growth Factor/genetics; Factor IX/genetics; Fibrillin-1; Fibrillins; Glycine/chemistry; Glycine/genetics; Humans; Microfilament Proteins/genetics; Mutation; Serine/chemistry; Serine/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Factor IX / Protein Folding / Epidermal Growth Factor / Microfilament Proteins Type of study: Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 1998 Document type: Article Affiliation country: United kingdom

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