Loss of merlin-p85 protein complex in NF2-related tumors.
Int J Oncol
; 12(5): 1073-8, 1998 May.
Article
in En
| MEDLINE
| ID: mdl-9538131
ABSTRACT
The NF2 tumor suppressor gene product, designated merlin, belongs to the family of molecules that links membranous protein with the cytoskeleton. We have previously shown that merlin was co-immunoprecipitated with a cellular protein, p85, in cultured cell. To analyze the alteration of merlin and associated proteins in surgical specimens, we developed a new method for biotin-labeling of whole cellular proteins. Screening of tumor tissues using our method showed that none of malignant gliomas and half of the NF2-related tumors had altered p85 and merlin. Our detection method seems useful for the screening of merlin alterations in NF2-related tumors.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Genes, Neurofibromatosis 2
/
Avian Proteins
/
Cytoskeletal Proteins
/
Glioma
/
Membrane Proteins
Limits:
Humans
Language:
En
Journal:
Int J Oncol
Journal subject:
NEOPLASIAS
Year:
1998
Document type:
Article
Affiliation country:
Japan