Dual effect of propranolol on the human platelet activation by thrombin: potentiation of free intracellular Ca2+ mobilization and inhibition of phospholipase D activity.

Svetlov, S I; Hanahan, D J

Svetlov, S I; Hanahan, D J.

Affiliation

Svetlov SI; Department of Biochemistry, University of Texas Health Science Center, San Antonio 78240-7760, USA.

Adv Exp Med Biol ; 400A: 199-205, 1997.

Article in En | MEDLINE | ID: mdl-9547558

Subject(s)

Blood Platelets/metabolism; Calcium/blood; Glycerophospholipids; Phospholipase D/blood; Platelet Activation/drug effects; Propranolol/pharmacology; Thrombin/pharmacology; Blood Platelets/drug effects; Enzyme Inhibitors/pharmacology; Humans; In Vitro Techniques; Kinetics; Naphthalenes/pharmacology; Phosphatidic Acids/blood; Phospholipase D/antagonists & inhibitors; Platelet Activation/physiology; Protein Kinase C/antagonists & inhibitors

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Collection: 01-internacional Database: MEDLINE Main subject: Phospholipase D / Propranolol / Blood Platelets / Thrombin / Platelet Activation / Calcium / Glycerophospholipids Limits: Humans Language: En Journal: Adv Exp Med Biol Year: 1997 Document type: Article Affiliation country: United States

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