[Therapy of vasomotor syndrome in the treatment of advanced prostatic cancer: apropos of 37 cases]. / Terapia della sindrome vasomotoria nel trattamento del cancro prostatico avanzato: a proposito di 37 casi.
Arch Ital Urol Androl
; 70(1): 37-40, 1998 Feb.
Article
in It
| MEDLINE
| ID: mdl-9549167
ABSTRACT
Castration, whether surgical (orchiectomy) or pharmacological (androgen blockade), used in the management of advanced prostatic carcinoma, induces as a secondary effect, immediately following impotence, the onset of a vasomotor syndrome characterized by hot flushes and sweating. This syndrome which may present with such intensity and frequency as to severely affect the quality of life and even the psychological equilibrium of the patient. Treatment with progestinic agents leads to the release of opioid peptides at hypothalamic level, thus decreasing the level of catecholamines responsible for the vasomotor syndrome. In the 37 cases treated with progestogens, a therapeutic efficacy of 80% was observed following cyproterone acetate and of 70% following medroxyprogesterone acetate.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Castration
/
Cyproterone Acetate
/
Hot Flashes
/
Androgen Antagonists
Aspects:
Patient_preference
Limits:
Aged
/
Humans
/
Male
/
Middle aged
Language:
It
Journal:
Arch Ital Urol Androl
Journal subject:
MEDICINA REPRODUTIVA
/
NEFROLOGIA
/
UROLOGIA
Year:
1998
Document type:
Article