Three-fold effect of lovastatin treatment on low density lipoprotein metabolism in subjects with hyperlipidemia: increase in receptor activity, decrease in apoB production, and decrease in particle affinity for the receptor. Results from a novel triple-tracer approach.

Berglund, L; Witztum, J L; Galeano, N F; Khouw, A S; Ginsberg, H N; Ramakrishnan, R

Berglund, L; Witztum, J L; Galeano, N F; Khouw, A S; Ginsberg, H N; Ramakrishnan, R.

Affiliation

Berglund L; Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.

J Lipid Res ; 39(4): 913-24, 1998 Apr.

Article in En | MEDLINE | ID: mdl-9555954

Subject(s)

Apolipoproteins B/pharmacokinetics; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Hyperlipidemias/metabolism; Lipoproteins, LDL/pharmacokinetics; Lovastatin/pharmacology; Receptors, LDL/metabolism; Adult; Animals; Apolipoproteins B/drug effects; Female; Guinea Pigs; Humans; Kinetics; Lipids/blood; Male; Middle Aged; Models, Theoretical; Receptors, LDL/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apolipoproteins B / Receptors, LDL / Lovastatin / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Hyperlipidemias / Lipoproteins, LDL Limits: Adult / Animals / Female / Humans / Male / Middle aged Language: En Journal: J Lipid Res Year: 1998 Document type: Article Affiliation country: United States Country of publication: United States

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