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Soluble molecules as biological markers in Hodgkin's disease.
Nadali, G; Vinante, F; Chilosi, M; Pizzolo, G.
Affiliation
  • Nadali G; Department of Haematology, University of Verona, Italy.
Leuk Lymphoma ; 26 Suppl 1: 99-105, 1997 Dec.
Article in En | MEDLINE | ID: mdl-9570686
ABSTRACT
Hodgkin's disease (HD) is characterised by a complex architectural and functional derangement of involved tissues. The interactions between neoplastic cells and the heterogeneous microenvironment lead to the expression and release of different cellular messengers [cytokines, soluble (s) forms of cytokine receptors and other membrane-associated molecules] which can be detected in the circulation and evaluated as biological markers. We and others investigated several of these molecules looking for their possible role as diagnostic or prognostic parameters in patients with HD. We update here the results of serum determination of sIL-2Ralpha, sCD8, sICAM-1, sTNFRs, and sCD30 in a large series of cases from our institution. We found that their levels are generally increased at presentation and during the active phase of the disease. They correlate with stage and clinical aggressiveness and have some prognostic implication. However, we were unable to demonstrate a prognostic usefulness for their detection, with the exception for sCD30 which was found to directly correlate with disease spread and burden at presentation and, most importantly, to have an independent prognostic significance. The prognostic significance of sCD30 might derive from a crucial involvement of this molecule in the pathophysiology of HD.
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Collection: 01-internacional Database: MEDLINE Main subject: Hodgkin Disease / Biomarkers, Tumor Type of study: Diagnostic_studies / Prognostic_studies Limits: Adult / Humans Language: En Journal: Leuk Lymphoma Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 1997 Document type: Article Affiliation country: Italy
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Collection: 01-internacional Database: MEDLINE Main subject: Hodgkin Disease / Biomarkers, Tumor Type of study: Diagnostic_studies / Prognostic_studies Limits: Adult / Humans Language: En Journal: Leuk Lymphoma Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 1997 Document type: Article Affiliation country: Italy
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