[Early detection of atherosclerosis with high resolution ultrasound exemplified by type II diabetic patients]. / Atherosklerose-Früherkennung mit hochauflösendem Ultraschall am Beispiel von Typ II-Diabetikern.
Ultraschall Med
; 19(1): 16-21, 1998 Feb.
Article
in De
| MEDLINE
| ID: mdl-9577888
ABSTRACT
AIM:
Endothelial Dysfunction (ED) is an early functional marker and Intima-Media-Thickness (IMT) an early morphological parameter of atherogenesis. Is there a simple, non-invasive routine method for the identification of atherosclerosis including the detection of the early functional endothelial impairment seen for example in Type 2 diabetic patients?METHODS:
Using high resolution ultrasound we studied peripheral endothelial function expressed as flow-associated dilation (FAD %) and endothelial independent vasodilation after administration of 400 micrograms glycerol trinitrate (postnitro %) of the brachial artery as well as IMT of the common carotid artery in 25 Type 2 diabetic patients and their matched controls.RESULTS:
(mean +/- SD) The diabetic patients showed a remarkable ED (FAD% 3.8 +/- 3.3 vs. 6.9 +/- 4.4%, p = 0.01) and an already increased IMT (0.72 +/- 0.14 vs. 0.62 +/- 0.10 mm, p < 0.01). The similar postnitro % in diabetic patients and controls suggests normal dilating capacity of the studied vessels in the diabetic patients (postnitro % 14.3 +/- 9.4 vs. 14.9 +/- 8.5%, p = ns).CONCLUSION:
With a combination of these three sonomorphological parameters it is possible to document the stage of atherosclerosis including endothelial dysfunction in Type 2 diabetic patients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arteriosclerosis
/
Diabetes Mellitus, Type 2
/
Diabetic Angiopathies
Type of study:
Diagnostic_studies
/
Screening_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
De
Journal:
Ultraschall Med
Year:
1998
Document type:
Article