Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.

Sussel, L; Kalamaras, J; Hartigan-O'Connor, D J; Meneses, J J; Pedersen, R A; Rubenstein, J L; German, M S

Sussel, L; Kalamaras, J; Hartigan-O'Connor, D J; Meneses, J J; Pedersen, R A; Rubenstein, J L; German, M S.

Affiliation

Sussel L; Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94143, USA.

Development ; 125(12): 2213-21, 1998 Jun.

Article in En | MEDLINE | ID: mdl-9584121

Subject(s)

Diabetes Mellitus/etiology; Genes, Homeobox; Homeodomain Proteins/genetics; Islets of Langerhans/cytology; Transcription Factors/genetics; Animals; Blood Glucose/analysis; Cell Differentiation; Cell Lineage; DNA-Binding Proteins/genetics; Eye Proteins; Gene Targeting; Glucagon/biosynthesis; Glucagon/genetics; Homeobox Protein Nkx-2.2; Homeodomain Proteins/physiology; Immunohistochemistry; Insulin/biosynthesis; Insulin/genetics; Islets of Langerhans/embryology; Islets of Langerhans/metabolism; Mice; Mutation; PAX6 Transcription Factor; Paired Box Transcription Factors; Pancreatic Polypeptide/biosynthesis; Pancreatic Polypeptide/genetics; Repressor Proteins; Somatostatin/biosynthesis; Somatostatin/genetics; Transcription Factors/physiology; Zebrafish Proteins

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Genes, Homeobox / Islets of Langerhans / Homeodomain Proteins / Diabetes Mellitus Limits: Animals Language: En Journal: Development Journal subject: BIOLOGIA / EMBRIOLOGIA Year: 1998 Document type: Article Affiliation country: United States Country of publication: United kingdom

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