[How can we measure a diameter of each entrance of a ion channel recording only channel conductance?]. / Kak izmerit' diametr kazhdogo vkhoda u ionnogo kanala, regestriruia tol'ko ego provodimost'?

ABSTRACT

The channel formed by colicin Ia in planar lipid bilayer was used to develop a method determining a diameter of each channel entrance. The method is based on measuring of a channel filling with nonelectrolytes through cis- and trans-entrance separately. To do this, one need to establish the two things only the conductance of an ion channel and the conductivity of used solutions. Using the method to predict the internal geometry of a channel lumen is discussed.