Endothelins inhibit mineralization of rat calvarial osteoblast-like cells.
J Cardiovasc Pharmacol
; 31 Suppl 1: S521-3, 1998.
Article
in En
| MEDLINE
| ID: mdl-9595531
ABSTRACT
We examined the effects of members of the endothelin (ET) family on mineralization of rat calvarial osteoblast-like cells. The accumulation of calcium in cells and cell layers was attenuated by ETs with the rank order of potency ET-1 = ET-2 > ET-3. We stained the mineralized nodules by von Kossa staining and measured the number and area of mineralized nodules. The inhibitory effects of ET-1 and ET-2 on the formation of mineralized nodules were stronger than those of ET-3. Our data suggest that ET-1 may inhibit the mineralization process of osteoblastic cells through the ETA receptor.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoblasts
/
Skull
/
Calcification, Physiologic
/
Endothelins
Limits:
Animals
/
Humans
Language:
En
Journal:
J Cardiovasc Pharmacol
Year:
1998
Document type:
Article
Affiliation country:
Japan