Design and synthesis of the first potent, selective, and cell penetrating adenosine 5'-monophosphate deaminase inhibitors.
Adv Exp Med Biol
; 431: 853-7, 1998.
Article
in En
| MEDLINE
| ID: mdl-9598184
ABSTRACT
A major milestone in purine metabolism research has been achieved with the discovery of these potent and selective AMPDA inhibitors. These inhibitors of AMPDA are based on carboxypentyl substitution on N-3 of the coformycin aglycon. They are simpler than coformycin ribose 5'-monophosphate, more stable, selective against other AMP binding enzymes as well as ADA and have good cell penetration and good oral bioavailability. These compounds and their more potent analogs are the first compounds with suitable characteristics to allow a definitive analysis of the role of AMPDA in cellular metabolism and AMPDA as a therapeutic target.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coformycin
/
Enzyme Inhibitors
/
AMP Deaminase
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Adv Exp Med Biol
Year:
1998
Document type:
Article
Affiliation country:
United States