Pharmacokinetic assessment of the sites of first-pass metabolism of BMS-181101, an antidepressant agent, in rats.

Vachharajani, N N; Shyu, W C; Shah, V R; Barbhaiya, R H

Vachharajani, N N; Shyu, W C; Shah, V R; Barbhaiya, R H.

Affiliation

Vachharajani NN; Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Company, Princeton, NJ 08540, USA.

J Pharm Pharmacol ; 50(3): 275-8, 1998 Mar.

Article in En | MEDLINE | ID: mdl-9600718

Subject(s)

Antidepressive Agents/pharmacokinetics; Intestinal Mucosa/metabolism; Liver/metabolism; Piperazines/pharmacokinetics; Pyrimidines/pharmacokinetics; Administration, Oral; Animals; Antidepressive Agents/administration & dosage; Antidepressive Agents/blood; Area Under Curve; Biological Availability; Carbon Radioisotopes; Infusions, Intravenous; Intestinal Absorption; Male; Piperazines/administration & dosage; Piperazines/blood; Pyrimidines/administration & dosage; Pyrimidines/blood; Rats; Rats, Sprague-Dawley

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Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Pyrimidines / Intestinal Mucosa / Liver / Antidepressive Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Pharm Pharmacol Year: 1998 Document type: Article Affiliation country: United States

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