5'-heterogeneity of the human excitatory amino acid transporter cDNA EAAT2 (GLT-1).
Neuroreport
; 9(7): 1295-7, 1998 May 11.
Article
in En
| MEDLINE
| ID: mdl-9631416
ABSTRACT
TWO novel transcripts of the human excitatory amino acid transporter EAAT2 (GLT-1) were cloned using PCR cloning techniques. Comparative sequence analysis of the 5'-untranslated region (UTR) of five EAAT2 transcripts led to the definition of five putative 5'-untranslated exons that are combined in a variable manner. Alternative splicing is a likely mechanism for the 5' complexity of the EAAT2 cDNA. The potential functional meaning of this finding such as differential expression of the EAAT2 transcripts in the central nervous system remains to be demonstrated.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription, Genetic
/
ATP-Binding Cassette Transporters
Limits:
Humans
Language:
En
Journal:
Neuroreport
Journal subject:
NEUROLOGIA
Year:
1998
Document type:
Article
Affiliation country:
Germany