Alpha-1 antitrypsin up-regulates human B cell differentiation selectively into IgE- and IgG4- secreting cells.

Jeannin, P; Lecoanet-Henchoz, S; Delneste, Y; Gauchat, J F; Bonnefoy, J Y

Jeannin, P; Lecoanet-Henchoz, S; Delneste, Y; Gauchat, J F; Bonnefoy, J Y.

Affiliation

Jeannin P; Geneva Biomedical Research Institute, Immunology Department, Glaxo Wellcome R&D SA, Switzerland.

Eur J Immunol ; 28(6): 1815-22, 1998 Jun.

Article in En | MEDLINE | ID: mdl-9645362

Subject(s)

B-Lymphocytes/drug effects; B-Lymphocytes/immunology; Immunoglobulin E/biosynthesis; Immunoglobulin G/biosynthesis; Serine Proteinase Inhibitors/pharmacology; Up-Regulation; alpha 1-Antitrypsin/pharmacology; Antibodies, Monoclonal/immunology; Antibodies, Monoclonal/pharmacology; CD40 Antigens/immunology; Cell Differentiation/drug effects; Cell Division; Cells, Cultured; Humans; Immunoglobulin E/genetics; Immunoglobulin epsilon-Chains/biosynthesis; Immunoglobulin epsilon-Chains/genetics; Interleukin-4/immunology; Neutralization Tests; Pancreatic Elastase/metabolism; RNA, Messenger; Receptors, Complement 3d/biosynthesis; Receptors, IgE/biosynthesis

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Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin E / Immunoglobulin G / B-Lymphocytes / Serine Proteinase Inhibitors / Up-Regulation / Alpha 1-Antitrypsin Limits: Humans Language: En Journal: Eur J Immunol Year: 1998 Document type: Article Affiliation country: Switzerland Country of publication: Germany

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