Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.

Colby, T D; Bahnson, B J; Chin, J K; Klinman, J P; Goldstein, B M

Colby, T D; Bahnson, B J; Chin, J K; Klinman, J P; Goldstein, B M.

Affiliation

Colby TD; Department of Biochemistry and Biophysics, University of Rochester Medical Center, New York 14642, USA.

Biochemistry ; 37(26): 9295-304, 1998 Jun 30.

Article in En | MEDLINE | ID: mdl-9649310

Subject(s)

Alcohol Dehydrogenase/chemistry; Alcohol Dehydrogenase/genetics; Liver/enzymology; Alanine/genetics; Alcohol Dehydrogenase/metabolism; Alcohol Oxidoreductases/chemistry; Animals; Binding Sites/genetics; Coenzymes/chemistry; Crystallography, X-Ray; Horses; Ligands; Models, Molecular; NAD/analogs & derivatives; NAD/chemistry; Niacinamide/chemistry; Phenylalanine/genetics; Structure-Activity Relationship; Substrate Specificity; Tryptophan/genetics; Valine/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Alcohol Dehydrogenase / Liver Type of study: Prognostic_studies Limits: Animals Language: En Journal: Biochemistry Year: 1998 Document type: Article Affiliation country: United States Country of publication: United States

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