Oxygen-regulated erythropoietin gene expression is dependent on a CpG methylation-free hypoxia-inducible factor-1 DNA-binding site.

Wenger, R H; Kvietikova, I; Rolfs, A; Camenisch, G; Gassmann, M

Wenger, R H; Kvietikova, I; Rolfs, A; Camenisch, G; Gassmann, M.

Affiliation

Wenger RH; Institute of Physiology, University of Zürich-Irchel, Zürich, Switzerland. labbauer@physiol.unizh.ch

Eur J Biochem ; 253(3): 771-7, 1998 May 01.

Article in En | MEDLINE | ID: mdl-9654078

Subject(s)

Cell Hypoxia; DNA-Binding Proteins/metabolism; Dinucleoside Phosphates/metabolism; Erythropoietin/biosynthesis; Gene Expression Regulation; Nuclear Proteins/metabolism; Animals; Binding Sites; Carcinoma, Hepatocellular; Cell Nucleus/metabolism; DNA Methylation; Gene Expression Regulation, Neoplastic; Genes, Reporter; HeLa Cells; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney/embryology; Kidney/growth & development; Kidney/metabolism; L Cells; Leukemia; Liver/embryology; Liver/growth & development; Liver/metabolism; Liver Neoplasms; Luciferases/biosynthesis; Mice; Neuroblastoma; Organ Specificity; Recombinant Fusion Proteins/biosynthesis; Transcription Factors/metabolism; Transcriptional Activation; Transfection; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Dinucleoside Phosphates / Cell Hypoxia / Gene Expression Regulation / Erythropoietin / DNA-Binding Proteins Limits: Animals / Humans Language: En Journal: Eur J Biochem Year: 1998 Document type: Article Affiliation country: Switzerland Country of publication: United kingdom

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