High throughput fluorescence-based conformation-sensitive gel electrophoresis (F-CSGE) identifies six unique BRCA2 mutations and an overall low incidence of BRCA2 mutations in high-risk BRCA1-negative breast cancer families.

Ganguly, T; Dhulipala, R; Godmilow, L; Ganguly, A

Ganguly, T; Dhulipala, R; Godmilow, L; Ganguly, A.

Affiliation

Ganguly T; Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104-6145, USA.

Hum Genet ; 102(5): 549-56, 1998 May.

Article in En | MEDLINE | ID: mdl-9654203

Subject(s)

BRCA1 Protein/genetics; Breast Neoplasms/genetics; DNA Mutational Analysis/methods; Mutation; Neoplasm Proteins/genetics; Transcription Factors/genetics; Adult; Aged; BRCA2 Protein; Breast Neoplasms, Male/genetics; Disease Susceptibility; Electrophoresis/methods; Evaluation Studies as Topic; False Negative Reactions; False Positive Reactions; Female; Fluorescence; Frameshift Mutation; Genetic Markers; Humans; Jews; Male; Middle Aged; Ovarian Neoplasms/genetics; Pedigree; Risk

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Breast Neoplasms / DNA Mutational Analysis / BRCA1 Protein / Mutation / Neoplasm Proteins Type of study: Diagnostic_studies / Etiology_studies / Evaluation_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Hum Genet Year: 1998 Document type: Article Affiliation country: United States Country of publication: Germany

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