Sigma ligands stimulate the electrical activity of frog pituitary melanotrope cells through a G-protein-dependent inhibition of potassium conductances.

Soriani, O; Vaudry, H; Mei, Y A; Roman, F; Cazin, L

Soriani, O; Vaudry, H; Mei, Y A; Roman, F; Cazin, L.

Affiliation

Soriani O; European Institute for Peptide Research (IFRMP no. 23), INSERM U413, UA CNRS, University of Rouen, Mont-Saint-Aignan, France.

J Pharmacol Exp Ther ; 286(1): 163-71, 1998 Jul.

Article in En | MEDLINE | ID: mdl-9655856

Subject(s)

GTP-Binding Proteins/physiology; Guanidines/pharmacology; Pentazocine/pharmacology; Pituitary Gland/drug effects; Potassium Channel Blockers; Receptors, sigma/physiology; Action Potentials/drug effects; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Male; Pituitary Gland/physiology; Rana ridibunda

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Collection: 01-internacional Database: MEDLINE Main subject: Pentazocine / Pituitary Gland / Receptors, sigma / GTP-Binding Proteins / Potassium Channel Blockers / Guanidines Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 1998 Document type: Article Affiliation country: France Country of publication: United States

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