Removal and degradation of the free MHC class II beta chain in the endoplasmic reticulum requires proteasomes and is accelerated by BFA.

Dusseljee, S; Wubbolts, R; Verwoerd, D; Tulp, A; Janssen, H; Calafat, J; Neefjes, J

Dusseljee, S; Wubbolts, R; Verwoerd, D; Tulp, A; Janssen, H; Calafat, J; Neefjes, J.

Affiliation

Dusseljee S; Divisions of Tumor Biology and Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, The Netherlands.

J Cell Sci ; 111 ( Pt 15): 2217-26, 1998 Aug.

Article in En | MEDLINE | ID: mdl-9664043

Subject(s)

Cyclopentanes/pharmacology; Cysteine Endopeptidases/metabolism; Endoplasmic Reticulum/metabolism; Histocompatibility Antigens Class II/metabolism; Multienzyme Complexes/metabolism; Protein Synthesis Inhibitors/pharmacology; Acetylcysteine/analogs & derivatives; Acetylcysteine/pharmacology; Anti-Bacterial Agents/pharmacology; Brefeldin A; Cell Fractionation; Cell Line; Cysteine Proteinase Inhibitors/pharmacology; Golgi Apparatus/metabolism; HLA-B27 Antigen/genetics; HLA-B27 Antigen/metabolism; Histocompatibility Antigens Class II/genetics; Humans; Kidney; Macrolides; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins

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Collection: 01-internacional Database: MEDLINE Main subject: Cysteine Endopeptidases / Protein Synthesis Inhibitors / Histocompatibility Antigens Class II / Cyclopentanes / Endoplasmic Reticulum / Multienzyme Complexes Limits: Humans Language: En Journal: J Cell Sci Year: 1998 Document type: Article Affiliation country: Netherlands Country of publication: United kingdom

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