Normal serum iron and ferritin concentrations in patients with Friedreich's ataxia.
Ann Neurol
; 44(1): 132-4, 1998 Jul.
Article
in En
| MEDLINE
| ID: mdl-9667602
ABSTRACT
Friedreich's ataxia (FRDA) is caused by point mutations or trinucleotide repeat expansions in both alleles of the gene encoding frataxin. Studies of frataxin homologues in lower eukaryotes suggest that mitochondrial iron accumulation may underlie the pathophysiology of FRDA. To evaluate the possible role of iron-chelation therapy for FRDA, we measured serum iron and ferritin concentrations in 10 FRDA patients. The measurements were within normal limits, suggesting that iron-chelation therapy for FRDA may be problematic.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Friedreich Ataxia
/
Ferritins
/
Iron
Limits:
Adolescent
/
Adult
/
Child
/
Humans
/
Middle aged
Language:
En
Journal:
Ann Neurol
Year:
1998
Document type:
Article
Affiliation country:
United States