D-amino acid containing, high-affinity inhibitors of recombinant human calpain I.

Chatterjee, S; Gu, Z Q; Dunn, D; Tao, M; Josef, K; Tripathy, R; Bihovsky, R; Senadhi, S E; O'Kane, T M; McKenna, B A; Mallya, S; Ator, M A; Bozyczko-Coyne, D; Siman, R; Mallamo, J P

Chatterjee, S; Gu, Z Q; Dunn, D; Tao, M; Josef, K; Tripathy, R; Bihovsky, R; Senadhi, S E; O'Kane, T M; McKenna, B A; Mallya, S; Ator, M A; Bozyczko-Coyne, D; Siman, R; Mallamo, J P.

Affiliation

Chatterjee S; Departments of Chemistry and Biochemistry, Cephalon, Inc., 145 Brandywine Parkway, West Chester, Pennsylvania 19380-4245, USA.

J Med Chem ; 41(15): 2663-6, 1998 Jul 16.

Article in En | MEDLINE | ID: mdl-9667954

Subject(s)

Amino Acids/chemical synthesis; Calpain/antagonists & inhibitors; Enzyme Inhibitors/chemical synthesis; Sulfonamides/chemical synthesis; Amino Acids/chemistry; Amino Acids/pharmacology; Binding Sites; Dipeptides/pharmacology; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Humans; Kinetics; Recombinant Proteins/antagonists & inhibitors; Stereoisomerism; Sulfonamides/chemistry; Sulfonamides/pharmacology; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Calpain / Enzyme Inhibitors / Amino Acids Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1998 Document type: Article Affiliation country: United States Country of publication: United States

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