A viral mechanism for inhibition of the cellular phosphatase calcineurin.
Science
; 281(5376): 562-5, 1998 Jul 24.
Article
in En
| MEDLINE
| ID: mdl-9677199
ABSTRACT
The transcription factor NFAT (nuclear factor of activated T cells) controls the expression of many immunomodulatory proteins. African swine fever virus inhibits proinflammatory cytokine expression in infected macrophages, and a viral protein A238L was found to display the activity of the immunosuppressive drug cyclosporin A by inhibiting NFAT-regulated gene transcription in vivo. This it does by binding the catalytic subunit of calcineurin and inhibiting calcineurin phosphatase activity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
Transcription, Genetic
/
Viral Proteins
/
Nuclear Proteins
/
Macrophages, Alveolar
/
African Swine Fever Virus
/
DNA-Binding Proteins
/
Calcineurin Inhibitors
Limits:
Animals
Language:
En
Journal:
Science
Year:
1998
Document type:
Article
Affiliation country:
United kingdom