Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation.
Science
; 281(5376): 572-5, 1998 Jul 24.
Article
in En
| MEDLINE
| ID: mdl-9677202
The T cell receptor (TCR) alphabeta heterodimer interacts with its ligands with high specificity, but surprisingly low affinity. The role of the zeta component of the murine TCR in contributing to the fidelity of antigen recognition was examined. With sequence-specific phosphotyrosine antibodies, it was found that zeta undergoes a series of ordered phosphorylation events upon TCR engagement. Completion of phosphorylation steps is dependent on the nature of the TCR ligand. Thus, the phosphorylation steps establish thresholds for T cell activation. This study documents the sophisticated molecular events that follow the engagement of a low-affinity receptor.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lymphocyte Activation
/
Receptors, Antigen, T-Cell
/
T-Lymphocytes
/
CD3 Complex
/
Membrane Proteins
Limits:
Animals
Language:
En
Journal:
Science
Year:
1998
Document type:
Article
Affiliation country:
United States
Country of publication:
United States