Genetic and functional studies of a germline TP53 splicing mutation in a Li-Fraumeni-like family.

Varley, J M; Chapman, P; McGown, G; Thorncroft, M; White, G R; Greaves, M J; Scott, D; Spreadborough, A; Tricker, K J; Birch, J M; Evans, D G; Reddel, R; Camplejohn, R S; Burn, J; Boyle, J M

Varley, J M; Chapman, P; McGown, G; Thorncroft, M; White, G R; Greaves, M J; Scott, D; Spreadborough, A; Tricker, K J; Birch, J M; Evans, D G; Reddel, R; Camplejohn, R S; Burn, J; Boyle, J M.

Affiliation

Varley JM; CRC Section of Molecular Genetics, Paterson Institute for Cancer Research, Manchester, UK.

Oncogene ; 16(25): 3291-8, 1998 Jun 25.

Article in En | MEDLINE | ID: mdl-9681828

Subject(s)

Alternative Splicing; Germ-Line Mutation/genetics; Li-Fraumeni Syndrome/genetics; Tumor Suppressor Protein p53/genetics; Adult; Apoptosis/genetics; Apoptosis/physiology; Family Health; Female; Fibroblasts/cytology; Fibroblasts/metabolism; Germ-Line Mutation/physiology; Humans; Li-Fraumeni Syndrome/physiopathology; Lymphocytes/cytology; Lymphocytes/metabolism; Male; Pedigree; Point Mutation/genetics; Point Mutation/physiology; Tumor Suppressor Protein p53/physiology; Yeasts/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Tumor Suppressor Protein p53 / Li-Fraumeni Syndrome / Alternative Splicing / Germ-Line Mutation Limits: Adult / Female / Humans / Male Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 1998 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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